Molecular biology and structure of a novel penaeid shrimp densovirus elucidate convergent parvoviral host capsid evolution
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Molecular biology and structure of a novel penaeid shrimp densovirus elucidate convergent parvoviral host capsid evolution
Black tiger shrimp (Penaeus monodon) is a comprehensive decapod crustaceans raised for human consumption. Currently, the virus from two different lineages of parvovirus (PV, family Parvoviridae; subfamily Hamaparvovirinae) infects penaeid shrimp.
Here, the PV was isolated and cloned from Vietnam specimens of P. monodon, Penaeus monodon appointed metallodensovirus (PmMDV). This was the first member of a different lineage third proved to infect penaeid decapods. PmMDV has the unique transcription strategy among PV invertebrates, extensive use of alternative splicing and transcription incorporating elements characteristic of PV-infect vertebrates. The PmMDV protein has no significant sequence similarity with other PV, except for the helicase domain SF3 its nonstructural protein.
The capsid structure, determined by cryoelectron microscope for 3-Å resolution, has a surface morphology similar to Penaeus stylirostris densovirus, despite the lack of significant capsid viral proteins (VP) of sequence similarity. Unlike other PV, VP crease PmMDV without combining βA multimer strand and shown a unique interaction, including the incorporation of cations Ca2 +, attach the N termini below fivefold icosahedral symmetry axis and forming a basket-like pentamer helix bundle. While the order PmMDV VP does not have a canonical domain of phospholipase A2, the structure of a capsid EDTA-treated, determined to 2.8-Å resolution, suggesting a mechanism cation-dependent membrane-penetrating alternative in the N-terminal region.
PmMDV is observed examples of convergent evolution between invertebrates PV capsid structure in connection with the host-driven and unique as PV shows the structure of the cation-sensitive cart / egress endosomal depending on the alternative. Bioinformatics is a very resourceful tool for understanding the evolution of membrane proteins, such as transient receptor potential channel. bioinformatics expert users rely on special scripting and programming skills. Some web servers and standalone tools are available to users nonadvanced is willing to develop projects to understand their system of choice.
Molecular biology and structure of a novel penaeid shrimp densovirus elucidate convergent parvoviral host capsid evolution
molecular biology and evolution of cancer: from discovery to action.
Cancer development is an evolutionary process. During this process, the growing population of cancer cells undergo limit the ecological niches in the body, such as primary tumor, circulatory system, and metastatic sites vary. heterogeneous population of cancer cells undergo selection for adaptive phenotypes, which form the molecular genetic variations in the same genetic drift. cell lineage underwent convergent evolution towards a phenotype known as hallmarks of cancer that promote cancer initiation, growth, and metastasis.
Efforts to prevent or delay cancer evolution-and-development requires a deep understanding of the underlying process of molecular evolution. Here we discuss the suite concept and tools of the theory of evolution and ecology that can inform-and possibly change-cancer biology in new ways and means. These concepts and tools including comparative research on cancer throughout the different species and the application of phylogenetic approaches to analyze the evolution of tumor progression and metastasis.
Tetrahydrofuran Mix (THF) - 3 pack of 1.5mL ampules
Description: A competitive Inhibition ELISA kit for detection of 5-Methyltetrahydrofolate from General in samples from blood, serum, plasma, cell culture fluid and other biological fluids.
Description: 5-formyltetrahydrofolate cyclo-ligase (MTHFS) belongs to the 5-formyltetrahydrofolate cyclo-ligase family. It is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, contributes to tetrahydrofolate metabolism. MTHFS helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion.
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Description: This is Competitive Enzyme-linked immunosorbent assay for detection of General 5-Methyltetrahydrofolate (5-Me-THF) in serum, plasma and other biological fluids.
General 5-Methyltetrahydrofolate (5-Me-THF) ELISA Kit
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of General 5-Methyltetrahydrofolate (5-Me-THF) in serum, plasma and other biological fluids.
General 5-Methyltetrahydrofolate (5-Me-THF) ELISA Kit
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of General 5-Methyltetrahydrofolate (5-Me-THF) in serum, plasma and other biological fluids.
General 5-Methyltetrahydrofolate (5-Me-THF) ELISA Kit
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of General 5-Methyltetrahydrofolate (5-Me-THF) in serum, plasma and other biological fluids.
General 5-Methyltetrahydrofolate (5-Me-THF) ELISA Kit
Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of General 5-Methyltetrahydrofolate (5-Me-THF) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species.
General 5-Methyltetrahydrofolate ELISA Kit (5-Me-THF)
Description: A wide range of well-characterized bioactive molecules that covers various targets related to cancer biology, including p53, EGFR and PKC etc. Facilitate your research towards the insights of gene regulation, tumorgenesis and immunotherapy etc.
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Fitness landscape can be used to describe the evolution of the potential trajectory of cancer, positive selection and mapping of neutral evolution of proto-oncogenes, tumor suppressor, and other functional elements. We also highlight the current challenges to implement these concepts and propose the research area, by incorporating these concepts, identify the mode of new therapies and in cancer susceptibility.
